Curcumin, COX-2, and Protein p300/CBP

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منابع مشابه

Curcumin, COX-2, and Protein p300/CBP

Received September 11, 2014. Accepted September 14, 2014. Correspondence to: Kyung Joon Lim Department of Anesthesiology and Pain Medicine, Chosun University School of Medicine, 365 Pilmun-daero, Dong-gu, Gwangju 501-717, Korea Tel: +82-62-220-3223, Fax: +82-62-223-2333, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non...

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Curcumin analogues were evaluated for COX-2 inhibitory as anti-inflammatory activities. The designed analogues significantly enhance COX-2 selectivity. The three compounds could dock into the active site of COX-2 successfully. The binding energies of -8.2, - 7.6 and -7.5 kcal/mol were obtained for three analogues of curcumin respectively. Molecular docking study revealed the binding orientation...

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Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway

Curcumin, a natural polyphenolic compound, has commonly been used as a food additive or in many traditional medicine remedies for over 2,000 years in many Asian countries. Melatonin is a hormone secreted from pineal glands of mammals and possesses diverse physiological functions. Both curcumin and melatonin have the effective potential to inhibit proliferation of various types of cancers, but t...

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ژورنال

عنوان ژورنال: The Korean Journal of Pain

سال: 2014

ISSN: 2005-9159,2093-0569

DOI: 10.3344/kjp.2014.27.4.365